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RankedFacts.com > Blog > Lifestyle > Wellness > Top 10 Pandemics Humanity Has Overcome
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Top 10 Pandemics Humanity Has Overcome

RankedFacts Team
Last updated: August 4, 2025 11:20 am
RankedFacts Team
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Top 10 Pandemics Humanity Has Overcome
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In today’s interconnected world, with easy access to global transportation and trade, viral outbreaks can spread rapidly. However, global pandemics aren’t a new phenomenon. Throughout history, humanity has faced numerous health crises. Here’s a look at 10 pandemics we have survived:

Contents
1. 1968 Hong Kong Flu Pandemic2. 1956 Asian Flu3. 1889 Russian Coronavirus Pandemic4. Antonine Plague of 165 AD5. Plague of Justinian 541-549 AD6. Black Death of 13467. Spanish Flu of 19188. 3rd Cholera Pandemic of 18529. 6th Cholera Pandemic of 191010. HIV Pandemic of 1981

1. 1968 Hong Kong Flu Pandemic

Forgotten pandemic: what's changed since the Hong Kong flu?

In July 1968, an unusual case of influenza emerged in Hong Kong. This H3N2 strain, an offshoot of H2N2, spread quickly. Within two weeks, cases appeared in Singapore and Vietnam. Within three months, it reached Australia, India, Europe, and the United States.

With a mortality rate of 0.5%, it was relatively low, but the Hong Kong Flu still caused significant damage. By the time it was contained, over a million people had died, including over 500,000 in Hong Kong alone, devastating nearly 15% of its population.

The strain shared traits with the Asian Flu of 1957, which is believed to have helped people develop antibodies, potentially lowering the number of casualties.

2. 1956 Asian Flu

The Silent Invader (Westinghouse Broadcasting, 1957)

The Asian Flu pandemic also originated in China, claiming over 2 million lives. A blend of Avian strains, it was first reported in Singapore in 1956. It then spread across China before reaching the US coast in 1957.

The World Health Organization reported that nearly 70,000 people died in the United States alone, with many more deaths worldwide during its two-year course.

3. 1889 Russian Coronavirus Pandemic

COVID-1889? Was the Russian "flu" a coronavirus? A better comparison to SARS than the 1918 flu.

The first reports of this flu outbreak surfaced in Turkestan, Northwestern Canada, and Greenland in May 1889. Initially thought to be virus subtype H2N2, it was recently discovered to be coronavirus subtype H3N8.

The outbreak spread quickly due to population growth and modern transportation. Within five weeks, it reached its peak, resulting in over a million lives lost.

The 1889 Influenza was considered the first real epidemic of the bacteriology age. Scientists have studied its patterns for years, gleaning valuable insights into pathology.

4. Antonine Plague of 165 AD

Roman soldiers returning from Mesopotamia and the war with Parthia brought back a plague that killed nearly 5 million people. It is believed to have been smallpox or measles.

It devastated the Roman army before spreading to Egypt, Greece, Italy, and Asia Minor. With the army weakened, the land was vulnerable to attacks, leading to civil unrest and barbarian invasions. This outbreak is thought to have contributed to the fall of the Pax Romana era.

5. Plague of Justinian 541-549 AD

The Justinian Plague: First Pandemic? // Procopius (541-542) // Byzantine Primary Source

Considered by some as the first known pandemic, the Plague of Justinian, named after Roman emperor Justinian I, is believed to have killed nearly half the population of Europe.

It was the first recorded outbreak of the bubonic plague and wreaked havoc across Roman Egypt, the Mediterranean Sea, the Arabian Peninsula, and Northern Europe over an eight-year span.

At its height, it killed nearly 5,000 people a day in Constantinople. It’s estimated that 25 to 100 million lives were lost. The social impact was wide-ranging, leading to grain demand and increased prices, weakening the Byzantine Empire.

6. Black Death of 1346

History of the Black Death - Full Documentary

One of history’s most infamous plagues, the Black Death, swept through Africa, Asia, and Europe between 1346 and 1353. This bubonic plague outbreak devastated Europe, wiping out approximately 50% of its population.

Spread by fleas traveling on rats aboard merchant ships, the estimated death toll ranged from 80 to 200 million. Bodies were burned or placed in mass graves.

The massive death toll led to a shortage of skilled labor, resulting in better pay and higher quality in food production, contributing to advancements in technology.

7. Spanish Flu of 1918

Spanish Flu: a warning from history

Despite its name, the Spanish Flu is not believed to have originated in Spain. Spain, being a neutral nation during World War I, had no press censorship, leading to earnest reporting of the outbreak, falsely associating the country as its origin.

World War I amplified the spread among soldiers in tight conditions and suffering from malnutrition. Over 500 million people were infected, with a mortality rate of 10-20%, causing nearly 25 million deaths in the first six months. Unlike other influenza strains, it targeted healthy young adults.

By its end in 1920, it had infected a third of the globe, claiming nearly 50 million lives.

8. 3rd Cholera Pandemic of 1852

The Pandemic the World Has Forgotten

Lasting eight years, this outbreak, like the first and second, is believed to have originated in India, spreading to Europe, Asia, Africa, and North America.

In London, British Physician Johnathan Snow traced the disease to a contaminated water source in 1854. He mapped reported cases, noticing a cluster around a water pump in a single neighborhood, a discovery that helped control the spread.

The Cholera Pandemic of 1852 took over a million lives.

9. 6th Cholera Pandemic of 1910

10. Asiatic Cholera (II): Five Pandemics

Much like the third pandemic, the Sixth Cholera Pandemic originated in India, where over 800,000 people died, before spreading to the Middle East, North Africa, Russia, and Eastern Europe.

Learning from the past, American health authorities acted swiftly, locating and isolating the infected to prevent the spread. Only 11 recorded deaths occurred in the United States.

As understanding of Cholera’s spread grew, the threat was largely reduced in the early 1920s, although parts of India are still affected today.

10. HIV Pandemic of 1981

1985 "AIDS: An Incredible Epidemic" by San Francisco General Hospital

Accounts of the first HIV case vary, with some claiming it was in Norway in the late 60s and others in the Democratic Republic of the Congo in 1976. Most scientists believe it developed from a chimpanzee virus that transferred to humans in West Africa in the 1920s. The first US case was reported in 1981.

Without understanding of the virus or its spread, fear grew as it became a global crisis, claiming over 36 million lives since its discovery.

With no cure, new drugs and procedures were discovered in the 1990s, eventually controlling the virus. Today, there are approximately 35 million people living with HIV, with over 60% in Sub-Saharan Africa, managing normal lives with treatment. In early 2020, two people were reported cured through stem cell replacement programs.

Global pandemics have been a part of life throughout history, but humanity has shown the ability to overcome them with dedication, compassion, and intelligence.

Share your thoughts on these historical events or other pandemics that have shaped humanity in the comments below!

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TAGGED:advertising historyalternative healthalzheimers diseaseamazing survivalsarchive odditiesBlack Plaguecholerainfluenzapandemicsviral outbreaks

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